Fig. 2
From: Advancement in research and therapy of NF1 mutant malignant tumors
The role of NF1 in resistance to anticancer therapeutics. NF1 might be involved in resistance to anticancer therapeutics through several mechanisms, which included: NF1 downregulated MCL1 expression and endowed cells with cisplatin resistance; NF1 mutations leaded to tamoxifen acquired resistance and the mechanism was still uncertain; NF1 mutations participated in TKIs resistance via promoting glycolysis, angiogenesis, EMT, cellular proliferation and survival. GTP = guanosine triphosphate. RAS = rat sarcoma viral oncogene homologue. GDP = guanosine diphosphate. RAF = murine sarcoma viral oncogene homologue. MEK = MAPK-ERK kinase. PI3K = phosphatidylinositol-3–kinase. AKT = V-akt murine thymoma viral oncogene homologue 1. mTOR = mammalian target of rapamycin. Rac1 = Ras-related C3 botulinum toxin substrate 1. PAK1 = P21-Activated Kinase