Skip to main content

Table 2 Validated ceRNA networks shaped by the ceRNA function of lncRNAs in HCC

From: The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

ceRNA network type ceRNA member Shared miRNA(s) Competing target (mRNA) ceRNA role Experiments related to mechanism Related HCC function mechanisms Ref
LncRNA–miRNA–mRNA HULC miR-372 PRKACB Oncogenic Cellular Invasion and metastasis [12]
   miR-6825-5p, miR-6845-5p, miR-6886-3p USP22 Oncogenic shRNA knockdown in mouse xenografts Chemosensitivity [52]
   miR-200a-3p ZEB1 Oncogenic siRNA knockdown in mouse xenografts Invasion and EMT [53]
   miR-186 HMGA2 Oncogenic Overexpression, antimiRs in mouse xenografts Proliferation [54]
  HOTAIR miR-122 DNMTs Oncogenic shRNA knockdown in mouse xenografts Proliferation [55]
   miR-23b-3p ZEB1 Oncogenic Overexpression in mouse xenografts Invasion and EMT [56]
  MALAT1 miR-30a-5p Vimentin Oncogenic shRNA knockdown in mouse xenografts Migration and invasion [57]
   miR-204 SIRT1 Oncogenic Cellular Migration and invasion [58]
   miR-143-3p ZEB1 Oncogenic Cellular Proliferation and invasion [59]
  MIAT miR-214 EZH2 Oncogenic siRNA knockdown in mouse xenografts Proliferation and invasion [60]
  LINC00974 miR-642 KRT19 Oncogenic shRNA knockdown in mouse xenografts Proliferation and metastasis [61]
  CCAT1 Let-7 HMGA2, c-Myc Oncogenic Cellular Proliferation and migration [62]
  DANCR miR-214, miR-320a, miR-199a CTNNB1 Oncogenic siRNA knockdown in mouse xenografts Invasion and metastasis [63]
   miR-27a-3p ROCK1, LIMK1, COFILIN1 Oncogenic shRNA knockdown in mouse xenografts Proliferation and metastasis [64]
   miR-216a-5p KLF12 Oncogenic shRNA knockdown in mouse xenografts Migration and invasion [65]
  HOTTIP miR-125b HOXA Oncogenic shRNA knockdown in mouse xenografts Proliferation and migration [66]
  ATB miR-200 family ZEB1, ZEB2 Oncogenic Overexpression, knockdown in mouse xenografts Invasion and EMT [67]
  UCA1 miR-216b FGFR1 Oncogenic siRNA knockdown in mouse xenografts Proliferation and metastasis [68]
   miR-203 Snail2 Oncogenic shRNA knockdown in mouse xenografts Proliferation and invasion [69]
  FAL1 miR-1236 AFP, ZEB1 Oncogenic Cellular Proliferation and migration [70]
  MUF miR-34a Snail1 Oncogenic overexpression in mouse xenografts EMT [71]
  HOXD-AS1 miR-130a-3p SOX4 Oncogenic shRNA knockdown in mouse xenografts Migration and invasion [72]
  SNHG8 miR-149-5p PPM1F Oncogenic shRNA knockdown in mouse xenografts Proliferation and metastasis [73]
  CDKN2B-AS1 let-7c-5p NAP1L1 Oncogenic shRNA knockdown in mouse xenografts Proliferation and metastasis [74]
  FLVCR1-AS1 miR-513c MET Oncogenic shRNA knockdown in mouse xenografts Proliferation, migration and invasion [75]
  ZFAS1 miR-150 ZEB1, MMP14, MMP16 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation and metastasis [76]
  NEAT1 miR-485 STAT3 Oncogenic Cellular Migration and invasion [77]
  TUG1 miR-142-3p ZEB1 Oncogenic shRNA knockdown in mouse xenografts Proliferation and EMT [78]
   miR-144 JAK2 Oncogenic shRNA knockdown in mouse xenografts Proliferation and migration [79]
  ANRIL miR-122-5p NR Oncogenic shRNA knockdown in mouse xenografts Proliferation and metastasis [80]
  n335586 miR-924 CKMT1A Oncogenic Overexpression in mouse xenografts Migration and invasion [81]
  HOXA-AS2 miR-520c-3p GPC3 Oncogenic shRNA knockdown in mouse xenografts Proliferation and EMT [82]
  PCAT-1 miR-215 CRKL Oncogenic shRNA knockdown, miR upregulation in mouse xenografts Proliferation [83]
  MCM3AP-AS1 miR-194-5p FOXA1 Oncogenic shRNA knockdown in mouse xenografts Proliferation [84]
  SNHG6-003 miR-26a/b TAK1 Oncogenic Overexpression in mouse xenografts Proliferation [85]
  TP73-AS1 miR-200a HMGB1, RAGE Oncogenic Cellular Proliferation [86]
  DSCR8 miR-485-5p FZD7 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation [87]
  LINC00707 miR-206 CDK14 Oncogenic shRNA knockdown in mouse xenografts Proliferation, migration and invasion [88]
  AGAP2-AS1 miR-16-5p ANXA11 Oncogenic Overexpression, shRNA knockdown in mouse xenografts Proliferation and metastasis [89]
  miat miR-22-3p sirt1 Oncogenic Knockdown in mouse xenografts Proliferation [90]
  DSCAM-AS1 miR-338-3p CyclinD1, SMO Oncogenic shRNA knockdown in mouse xenografts Proliferation, migration and invasion [91]
  XIST miR-194-5p MAPK1 Oncogenic shRNA knockdown in mouse xenografts Proliferation, migration and invasion [92]
   miR-497-5p PDCD4 Tumor suppressive Overexpression in mouse xenografts Proliferation and metastasis [93]
   miR-92b Smad7 Tumor suppressive Overexpression, knockdown in mouse xenografts Proliferation and metastasis [94]
  LINC00657 miR-106a-5p PTEN Tumor suppressive shRNA knockdown in mouse xenografts Proliferation, migration and invasion [95]
  MEG3 miR-9-5p SOX11 Tumor suppressive Cellular Proliferation [96]
  SNHG16 miR-93 NR Tumor suppressive Overexpression in mouse xenografts Cell proliferation and chemosensitivity [97]
  CASC2 miR-367 FBXW7 Tumor suppressive Overexpression downregulation in mouse xenografts EMT [98]
  MIR31HG miR-575 ST7L Tumor suppressive shRNA knockdown in mouse xenografts Proliferation and metastasis [99]
  FTX miR-374a WIF1, PTEN, WNT5A Tumor suppressive Overexpression in mouse xenografts Invasion and EMT [100]
  1. ceRNA: competing endogenous RNA; lncRNA: long noncoding RNA; mRNAs: messenger RNAs; miRNA: microRNA; HCC: hepatocellular carcinoma; EMT: epithelial–mesenchymal transition; Ref: reference