Table 2 Univariate and multivariate analysis of overall survival in CRC patients
From: Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Gender (male vs. female) | 0.44 (0.17–1.13) | 0.088 |  |  |
Age (≤ 65 vs. > 65 years) | 0.85 (0.43–1.68) | 0.647 |  |  |
Tumor diameter (≤ 5 vs. > 5 cm) | 1.96 (0.99–3.85) | 0.052 |  |  |
Tumor location (colon vs. rectum) | 1.50 (0.76–2.96) | 0.240 |  |  |
Differentiation (well / moderate vs. poor) | 0.89 (0.39–2.06) | 0.794 |  |  |
pT stage (T1–T3 vs. T4) | 2.02 (1.02–4.01) | 0.043* | 2.42 (1.14–5.12) | 0.021* |
pN stage (N0 vs. N1–N2) | 1.60 (0.80–3.20) | 0.188 |  |  |
Distant metastasis (M0 vs. M1) | 7.11 (3.37–15.00) |  < 0.001* | 4.67 (2.01–10.82) |  < 0.001* |
pTNM stage (I–II vs. III–IV) | 5.28 (2.15–13.01) |  < 0.001* | 3.55 (1.38–9.16) | 0.009* |
Hsa_circ_0026416 expression (low vs. high) | 4.59 (1.99–10.59) |  < 0.001* | 3.11 (1.26–7.68) | 0.014* |