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Table 2 Univariate and multivariate analysis of overall survival in CRC patients

From: Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Variables Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Gender (male vs. female) 0.44 (0.17–1.13) 0.088   
Age (≤ 65 vs. > 65 years) 0.85 (0.43–1.68) 0.647   
Tumor diameter (≤ 5 vs. > 5 cm) 1.96 (0.99–3.85) 0.052   
Tumor location (colon vs. rectum) 1.50 (0.76–2.96) 0.240   
Differentiation (well / moderate vs. poor) 0.89 (0.39–2.06) 0.794   
pT stage (T1–T3 vs. T4) 2.02 (1.02–4.01) 0.043* 2.42 (1.14–5.12) 0.021*
pN stage (N0 vs. N1–N2) 1.60 (0.80–3.20) 0.188   
Distant metastasis (M0 vs. M1) 7.11 (3.37–15.00)  < 0.001* 4.67 (2.01–10.82)  < 0.001*
pTNM stage (I–II vs. III–IV) 5.28 (2.15–13.01)  < 0.001* 3.55 (1.38–9.16) 0.009*
Hsa_circ_0026416 expression (low vs. high) 4.59 (1.99–10.59)  < 0.001* 3.11 (1.26–7.68) 0.014*
  1. HR hazard ratio, CI confidence interval
  2. *Significant difference