Protein kinase function of pyruvate kinase M2 and cancer

Table 1 Select reported protein substrates of PKM2

Substrates	Amino acids	Functions	Reference
AKT1S1	Ser202, Ser203	mTORC1 signaling	He et al. [77]
Bcl2	Thr69	Apoptosis	Liang et al. [32]
Bub3	Tyr207	Cell cycle	Jiang et al. [28]
Histone H1			Ignacak and Stachurska [107]
Histone H3	Thr11	Gene transcription	Yang et al. [12]
Histone H2AX	Ser139	Genomic instability	Xia et al. [33]
MLC2	Tyr118	Cell cycle	Jiang et al. [29]
PAK2	Ser20, Ser141, Ser192, Ser197	Tumor invasion, metastasis	Cheng et al. [24]
SNAP-23	Ser95	Exosome release	Wei et al. [34]
STAT3	Tyr705, Thr454	Nuclear translocation, gene transcription	Gao et al. [20]; Yu et al. [61]
Interacting-partners when PKM2 serves as a transcription coactivator
β-catenin			Yang et al. [19]; Yang et al. [23]; Liang et al. [68]
HIF-1α			Luo et al. [69]
Oct4			Lee et al. [71]; Morfouace et al. [21]
STAT5a			Park et al. [70]

AKT1S1, AKT1 substrate 1; Bcl-2, B-cell lymphoma 2; Bub3, spindle checkpoint protein; HIF-1α, hypoxia inducible factors-1 alpha; MLC2, myosin light chain 2; Oct4, octamer-binding transcription factor 4; PAK2, p21-activated kinase 2; SNAP-23, synaptosome-associated protein 23; STAT: signal transducers and activators of transcription

ISSN: 1475-2867