Fig. 6

The depletion of KIF20A sensitized the resistant cells to docetaxel. VCaP-DR and DU145-DR cells were treated with siKIF20A and then DOC (25 nM). After administering DOC for 72 h, an MTT assay (a) or 14 days in a colony formation assay (b, c) were used to assess the viability of cells. d, e The invasive abilities of cells were assessed using a transwell invasion assay. f Kaplan–Meier survival analysis indicates that the association of KIF20A expression with poorer disease free survival was statistically significant. Data represents the mean ± SD of three experiments. ^*p < 0.05, ^**p < 0.01