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Fig. 4 | Cancer Cell International

Fig. 4

From: Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway

Fig. 4

Hsa_circ_0014235 overexpression enhanced DDP resistance and promoted cell malignant behaviors. a The efficiency of hsa_circ_0014235 overexpression was checked using qPCR. Then, DDP-treated A549 and H1299 cells were transfected with oe-circ or Vector, and b cell proliferation, c colony formation ability, d cell cycle progression, e cell invasion, f cell migration and g cell apoptosis were examined using CCK-8 assay, colony formation assay, flow cytometry assay, transwell assay, wound healing assay and flow cytometry assay, respectively. h The expression of MMP9, Bax, E-cadherin, Vimentin and MRP-1 in these cells was measured by western blot. *P < 0.05, **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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