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Fig. 4 | Cancer Cell International

Fig. 4

From: Extracellular vesicle-associated miR-135b and -135a regulate stemness in Group 4 medulloblastoma cells by targeting angiomotin-like 2

Fig. 4

Integrated analysis and validation of mRNA-targeted miRNAs in brain tumour spheroid-forming cells (BTSCs). a Differential gene expression between bulk tumour cells (BTCs) and BTSCs was determined by RNA-seq. According to the integrated analysis, there are 199 genes that are predicted to be targets of the 23 upregulated miRNAs. The number of previously identified targets for miR-135b and miR-135a targets is 1 and 3, respectively. b The predicted target genes for miR-135b or miR-135a were identified as AMOTL2, STAT6, GPX8, and their expression was verified by RT-qPCR. Compared with BTCs, the expression of AMOTL2, STAT6, and GPX8 was observed to be significantly reduced in BTSCs. ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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