Table 3 Summary of univariate and multivariate Cox regression analysis of overall survival duration. (Data from CGGA-693 database.)
From: MiR-4310 induced by SP1 targets PTEN to promote glioma progression
Univariate analysis | Multivariate analysis (Forward:LR) | |||||
|---|---|---|---|---|---|---|
p | HR | 95% CI | p | HR | 95% CI | |
Age | ||||||
0–20 | < 0.0001 | – | – | 0.089 | – | – |
20–50 | 0.04 | 0.229 | 0.056–0.932 | 0.029 | – | – |
50–80 | < 0.0001 | 0.436 | 0.325–0.584 | 0.507 | – | – |
Gender | 0.646 | 0.933 | 0.696–1.252 | 0.553 | – | – |
Grade | ||||||
WHO II | < 0.0001 | – | – | <0.0001 | – | – |
WHO III | < 0.0001 | 0.099 | 0.063–0.155 | <0.0001 | 0.127 | 0.074–0.219 |
WHO IV | < 0.0001 | 0.292 | 0.210–0.407 | <0.0001 | 0.431 | 0.291–0.639 |
IDH mutant | < 0.0001 | 4.576 | 3.350–6.250 | <0.0001 | 2.363 | 1.627–3.432 |
Radio status | 0.215 | 0.778 | 0.523–1.157 | 0.104 | – | – |
Chemo status | 0.035 | 0.69 | 0.489–0.974 | 0.004 | 1.787 | 1.207–2.645 |
sp1 | 0.002 | 0.628 | 0.466–0.846 | 0.006 | 0.643 | 0.468–0.883 |
PTEN | 0.003 | 1.561 | 1.166–2.090 | <0.0001 | 1.734 | 1.280–2.349 |