Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

Table 2 List of natural compounds and their target genes as well as their expression in bladder cancer

Natural compound	Cell line	Target gene	Expression	References
Resveratrol	T24, ECV-304	Bcl-2	Down-regulate	[88, 89]
	639Vs	mTORC1	Down-regulate	[93]
	RT4, 5637, T24	Akt, mTOR, SRC	Down-regulate	[102, 103]
	5637	Akt	Down-regulate	[105]
	5637	PTEN	Up-regulate	[105]
Curcumin	T24	P53	Down-regulate	[118]
	T24, J82, TCCSUP	Akt, SRC	Down-regulate	[119]
	EJ	PI3K	Suppress activation	[126]
Paclitaxel	T24	Akt	Down-regulate	[134]

ISSN: 1475-2867