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Fig. 3 | Cancer Cell International

Fig. 3

From: DLG1-AS1 is activated by MYC and drives the proliferation and migration of hepatocellular carcinoma cells through miR-497-5p/SSRP1 axis

Fig. 3

DLG1-AS1 boosts the proliferation and migration of HCC cells via sponging miR-497-5p. a FISH assay was applied to ascertain the cellular distribution of DLG1-AS1 in Hep3B and HCCLM3 cells. b Expression of 9 miRNAs in HCC cells and THLE-2 was detected by RT-qPCR. c A binding site between DLG1-AS1 and miR-497-5p. d RNA pull-down illustrated miR-497-5p bound to DLG1-AS1. e The efficiency of miR-497-5p overexpression in Hep3B and HCCLM3 cells. f Luciferase reporter assay demonstrated the relationship between DLG1-AS1 and miR-497-5p. g MiR-497-5p expression was examined by RT-qPCR in cells transfected with miR-497-5p inhibitor. h–m Cell proliferation, apoptosis, migration and invasion were appraised in cells transfected with sh-NC, sh-DLG1-AS1#1 and miR-497-5p inhibitor. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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