Fig. 1

Generation of 5-Fu and oxaliplatin resistant CRC cell lines. a Relative cell viability to 5-Fu in HT29 WT and HT29 5-Fu-R cell lines. Cells were treated with 0 µM, 1 µM, 2 µM, 4 µM, 8 µM of 5-Fu for 48 h. b Relative cell viability to 5-Fu in SW480 WT and SW480 5-Fu-R cell lines. Cells were treated with 0 µM, 2.5 µM, 5 µM, 10 µM, 20 µM of 5-Fu for 48 h. c Relative cell viability to oxaliplatin in HT29 WT, HT29 5-Oxa-R, d SW480 WT and SW480 Oxa-R cell lines. Cells were treated with 0 µM, 5 µM, 10 µM, 20 µM, 40 µM of oxalipatin for 48 h. The statistical analysis of cell viability was calculated by using one-way ANOVA. Variation is indicated and presented as mean ± SEM