Fig. 1

CD44 expression was lower in tumor compared with nontumor tissues and was positively correlated with PD-L1 in lung adenocarcinoma patients. a Lower expression of CD44 was found in tumors as compared with non-tumor tissues in patients with lung adenocarcinoma. b Positive correlation was found between CD44 and PD-L1(CD274) mRNA expressions using Tumor Immune Estimation Resource (TIMER). c Representative images were shown demonstrating CD44 and PD-L1 expression in tumors from lung adenocarcinoma patients with stage I and stage III. d Positive association was found between CD44 and PD-L1 in tumors from lung adenocarcinoma patients, as evaluated by immunohistology. e CD44 expression was analyzed in lung adenocarcinoma of different immunological subtypes. f Diagrams demonstrating anti-tumor drugs targeting CD44