Table 3 Univariate and multivariate analyses of prognostic factors in ICC (n = 359)
Variable | TTR | OS | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Univariate analysis | ||||
 Age, year (≤ 50 versus > 50) | 0.89 (0.63–1.28) | 0.551 | 1.29 (0.94–1.78) | 0.116 |
 Sex (female versus male) | 1.04 (0.77–1.39) | 0.809 | 1.07 (0.83–1.38) | 0.583 |
 HBsAg (negative versus positive) | 1.09 (0.80–1.50) | 0.577 | 0.72 (0.54–0.96) | 0.025 |
 AFP, ng/ml (≤ 20 versus > 20) | 1.17 (0.76–1.79) | 0.483 | 0.84 (0.56–1.26) | 0.396 |
 CA199 (≤ 36 versus > 36) | 1.19 (0.88–1.60) | 0.258 | 1.90 (1.46–2.48) | 0 |
 GGT,U/L (≤ 54 versus > 54) | 1.35 (1.00–1.81) | 0.05 | 1.92 (1.48–2.48) | 0 |
 Liver cirrhosis (no versus yes) | 1.16 (0.83–1.62) | 0.396 | 0.83 (0.61–1.12) | 0.226 |
 Tumor size, cm (≤ 5 versus > 5) | 1.38 (1.02–1.86) | 0.035 | 1.65 (1.28–2.14) | 0 |
 Tumor number (single versus multiple) | 2.48 (1.81–3.40) | 0 | 2.66 (2.03–3.47) | 0 |
 Microvascular/bile duct invasion (no versus yes) | 1.02 (0.70–1.48) | 0.937 | 1.48 (1.10–1.97) | 0.009 |
 Lymphatic metastasis (no versus yes) | 2.23 (1.52–3.28) | 0 | 2.70 (1.96–3.72) | 0 |
 Tumor encapsulation (complete versus none) | 1.91 (1.20–3.04) | 0.006 | 1.46 (1.01–2.11) | 0.042 |
 Tumor differentiation (I + II versus III + IV) | 1.10 (0.82–1.48) | 0.519 | 1.43 (1.11–1.84) | 0.005 |
 TNM stage (I versus II + III + IV) | 1.92 (1.42–2.59) | 0 | 2.78 (2.14–3.61) | 0 |
 Intra-pDCs (low versus high) | 1.16 (0.87–1.56) | 0.314 | 1.18 (0.91–1.51) | 0.208 |
 Peri-pDCs (low versus high) | 1.77 (1.29–2.44) | 0 | 1.87 (1.42–2.46) | 0 |
 Peri-Tregs (low versus high) | 1.63 (1.19–2.24) | 0.003 | 1.53 (1.17–2.01) | 0 |
 Peri-pDCs and Tregs (both low vs. both high) | 2.22 (1.49–3.31) | 0 | 2.17 (1.55–3.03) | 0 |
Multivariate analysis | ||||
 HBsAg (negative versus positive) | NA | NA | 0.70 (0.51–0.97) | 0.033 |
 CA199 (≤ 36 versus > 36) | NA | NA | 1.35 (1.01–1.82) | 0.045 |
 GGT, U/L (≤ 54 versus > 54) | NA | NA | 1.65 (1.24–2.21) | 0.001 |
 Tumor size, cm (≤ 5 versus > 5) | 1.05 (0.75–1.46) | 0.786 | 1.13 (0.84–1.51) | 0.435 |
 Tumor number (single versus multiple) | 1.94 (1.36–2.77) | 0 | 2.12 (1.57–2.86) | 0 |
 Microvascular/bile duct invasion (no versus yes) | NA | NA | 1.28 (0.91–1.79) | 0.153 |
 Lymphatic metastasis (no versus yes) | 1.72 (1.12–2.64) | 0.014 | 2.09 (1.45–3.00) | 0 |
 Tumor encapsulation (complete versus none) | 1.96 (1.18–3.25) | 0.009 | 1.58 (1.04–2.42) | 0.034 |
 Tumor differentiation (I + II versus III + IV) | NA | NA | 1.32 (1.00–1.74) | 0.051 |
 Peri-pDCs (low versus high) | 1.54 (1.11–2.14) | 0.01 | 1.55 (1.17–2.05) | 0.002 |
 Peri-Tregs (low versus high) | 1.59 (1.16–2.20) | 0.004 | 1.34 (1.02–1.77) | 0.036 |
 Peri-pDCs and Tregs (both low vs. both high) | 1.96 (1.30–2.94) | 0.001 | 1.74 (1.23–2.47) | 0.002 |