Fig. 1
From: SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1
SKP1 is associated with colorectal cancer stemness. a The mRNA level of SKP1 is upregulated in CRC spheres, compared with adherent and re-adherent cells. b, c The expression of SKP1 is positively correlated with cancer stem cell markers. The TCGA dataset was downloaded from R2 platform (b) and the mRNA levels of genes in tumor samples from 30 CRC patients were determined by qRT-PCR (c). Spearman analysis was performed for correlation analysis. d High expression of SKP1 is associated with poor prognosis of colon cancer patients. The TCGA dataset was downloaded from R2 platform. Kaplan–meier analysis was used for analysis of the relationship between SKP1 expression and survival of colon cancer patients. Student’s t-test (***p < 0.001)