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Fig. 4 | Cancer Cell International

Fig. 4

From: Circular RNA circPLK1 promotes breast cancer cell proliferation, migration and invasion by regulating miR-4500/IGF1 axis

Fig. 4

CircPLK1 silence inhibited BC cell growth, migration and invasion by downregulating IGF1. BT549 and HCC38 cells were transfected with sh-NC, sh-circPLK1, sh-circPLK1 + pcDNA3.0-NC, or sh-circPLK1 + pcDNA3.0-IGF1. a CCK-8 assay was employed to evaluate cell viability. b Cell cycle distribution was determined by flow cytometry. c, d The expression levels of CDK4 and CDK6 were analyzed by western blot analysis. e, f Cell migration and invasion were evaluated by transwell assay. ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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