Fig. 3
From: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis
Down-regulated miR-139-3p was targeted by PCAT6 in PA. a The expression levels of miR-137, miR-139-3p, miR-542-3p, miR-571, miR-578, miR-580, miR-31, miR-617, miR-658, and miR-507 in normal pituitary, NIPA, and IPA tissues were analyzed by RT-qPCR. U6 was used as an internal control. b The putative binding site between miR-486-3p and circFLNA was predicted by LncBase Predicted v.2. c, d The results of luciferase assay validated that lncRNA PCAT6 targeted miR-139-3p in PA cells RC-4B/C and GH3. e, f The relationship between PCAT6 and miR-139-3p was further assessed by RIP assay. (*P < 0.05, **P < 0.01, vs. Normal; ^^^P < 0.001, vs. MC; ###P < 0.01, vs. Anti-IgG). PA pituitary adenomas, IPA invasive pituitary adenomas, NIPA non-invasive pituitary adenomas, RIP RNA immunoprecipitation