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Fig. 3 | Cancer Cell International

Fig. 3

From: Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Fig. 3

The effect of emodin on the HA-CD44/RHAMM signaling pathway knocked down A549 cells. The expression of HAS2 and HAS3 (HAS2/3) or CD44 and RHAMM (CD44/RHAMM) were knocked down in A549 cells. a The effect of emodin on viability. The transfected cells were exposed to 30 µM emodin for 24 h before the MTT assay. b The effect of emodin on HA secretion of transfected A549 cells. c Representative image of western blotting. d–g The effect of emodin on the protein expression of HAS2, HAS3, CD44, and RHAMM in transfected A549 (Bar chart for western blotting). “*” marks the significant difference (p < 0.05) compare with the vehicle control (“−”)

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Cancer Cell International

ISSN: 1475-2867

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