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Fig. 5 | Cancer Cell International

Fig. 5

From: Anlotinib as a promising inhibitor on tumor growth of oral squamous cell carcinoma through cell apoptosis and mitotic catastrophe

Fig. 5

Nucleus chromosome instability and mitotic catastrophe were observed and visualized via immunofluorescence. Normal mitosis was presented in a bipolar pattern of spindles apparatus by α-Tubulin-labeled staining of immunofluorescence while in Anlotinib-treated group, spindles in cells were not heading to two but four poles or even more (a). Significant nuclear breakage was found in Anlotinib-treated group(20.1% and 30.21%) than in control group (5.4% and 3.043%) (*p < 0.05, **p < 0.01)

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Cancer Cell International

ISSN: 1475-2867

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