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Fig. 5 | Cancer Cell International

Fig. 5

From: TRAIL promotes hepatocellular carcinoma apoptosis and inhibits proliferation and migration via interacting with IER3

Fig. 5

TRAIL/IER3 inhibit Wnt/β-catenin signaling. a After stimulation with LiCl (20 mM), TOP/FOP ratio in a luciferase reporter assay revealed that TRAIL/IER3 synergistic effect impacted Wnt signaling in Huh7 cells. Renilla luciferase activity was used to normalize firefly luciferase activity for all samples, with experiments being repeated three times. **P < 0.01. b, c Immunofluorescence and Western blotting analysis were used to assess nuclear β-catenin, PARP, c-Myc, and survivin levels in Huh7 cells following TRAIL/IER3 synergistic effect. Scale bar = 10 µm

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Cancer Cell International

ISSN: 1475-2867

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