Fig. 3

Exosomal miR-34c inhibits fibroblast activation by targeting WNT1 (a, b) qRT-PCR analysis of WNT1 and western blotting analysis of WNT1, β-catenin and p-β-catenin in CCC-HSF-1 cells treated with or without miR-34 mimics and control. c Relative luciferase activity between wild-type and mutant-type binding site of miR-34c and WNT1. (d, e) Transcript and protein levels of WNT1 assessed in CCC-HSF-1 cells in the presence or absence of miR-34c mimics or inhibitor. **P < 0.01 vs. NCC-Exo groups;##P < 0.01 vs. NC-Exo groups; ^&&P < 0.01 vs. mimic NC groups; ^$$P < 0.01 vs. inhibitor NC groups