Fig. 5

Representative H&E-stained samples and immunohistochemical staining of ADAM10. a Two representative H&E-stained samples were diagnosed as invasive breast carcinoma of no special type and classified into Cohort 1 and Cohort 2, respectively, according to their different responses to neoadjuvant chemotherapy (NACT). Cohort 1: H&E-stained sample before and after NACT showed poor response to NACT. Cohort 2: H&E-stained sample before and after NACT showed good response to NACT. b Representative immunohistochemical staining intensity of ADAM10 scaled 0, 1, 2, 3 (Score 0: negative staining; Score 1: weak staining; Score 2: moderate staining; Score 3: strong staining). The positive staining of ADAM10 was detected in cytoplasm and cytomembrane. All representative images were taken on power of × 200