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Fig. 4 | Cancer Cell International

Fig. 4

From: Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis

Fig. 4

Linc00887 bound to miR-454-3p, and miR-454-3p overexpression rescued the inhibition of pcDNA-linc00887 on cell proliferation and invasion. a Starbase online (http://starbase.sysu.edu.cn/) was used to predict the relationship of wild-type linc00887 or mutant linc00887 with has-miR-454-3p. Dual fluorescein report gene assay (b) and Pull down assay (c) were used to verify the relationship between linc00887 and miR-454-3p. **p < 0.01 versus NC mimic or Biotin-labelled NC miRNA. d MiR-454-3p level was detected in immortalized squamous cells of human cervix (Ect1/E6E7) and cervical cancer (Hela and C33A) cell lines. **p < 0.01 versus Ect1/E6E7. e RT-qPCR was used to detect that the effect of miR-454-3p overexpression on miR-454-3p expression. **P < 0.01 versus NC mimic. f Effect of overexpression of linc00887 on miR-454-3p expression and knockdown of linc00887 on miR-454-3p expression. **p < 0.01 versus Vector or scramble. g Effect of pcDNA-linc00887 vector was transfected into Hela cells together with miR-454-3p mimic vector on miR-454-3p expression. **p < 0.01 versus Vector, NC mimic or pcDNA-linc00887 together with miR-454-3p mimic. h, i Effect of pcDNA-linc00887 vector was transfected into Hela cells together with miR-454-3p mimic vector on cell proliferation and invasion. **p < 0.01 versus Vector, NC mimic or pcDNA-linc00887 together with miR-454-3p mimic

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