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Fig. 6 | Cancer Cell International

Fig. 6

From: Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis

Fig. 6

FRMD6 bound to miR-454-3p, and the expression of FRMD6 mRNA was detected in cervical cancer cell lines. a Starbase online (http://starbase.sysu.edu.cn/) was used to predict the relationship of wild type FRMD6 or mutant FRMD6 with has-miR-454-3p. b Dual fluorescein report gene assay was used to verify the relationship of wild type FRMD6 or mutant FRMD6 with has-miR-454-3p in HEK293 cells. **p < 0.01 versus NC mimic. c Relative FRMD6 mRNA expression was detected in Ect1/E6E7, Hela, C33A, Caski, ME180 and Siha cell lines. **p < 0.01 versus Ect1/E6E7 cell line. d, e Effect of linc00887 siRNA transfected into Hela cell line together with miR-454-3p inhibitor on FRMD6 protein expression, which was detected by Western blot assay. Histogram (e) was the quantization of graph D. **p < 0.01 versus scramble alone or linc00887 siRNA together with scramble

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