Table 2 Univariate analysis of genetic mutations and recurrence survival rate
Gene | Alterations (%) | Total patients (n = 58) | BCG subgroup (n = 46) | ||
|---|---|---|---|---|---|
P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | ||
NEB | 5.2 | 0.001 | 17.307 (3.305–90.639) | 0.001 | 21.213 (3.466–129.823) |
MLH1 | 5.2 | 0.011 | 18.580 (1.933–178.630) | NA | NA |
CDKN1B | 3.4 | 0.011 | 18.580 (1.933–178.630) | NA | NA |
FGF12 | 1.7 | 0.011 | 18.580 (1.933–178.630) | 0.012 | 21.995 (1.994–242.587) |
NKX2_1 | 1.7 | 0.011 | 18.580 (1.933–178.630) | NA | NA |
RET | 1.7 | 0.011 | 18.580 (1.933–178.630) | NA | NA |
SDHB | 1.7 | 0.011 | 18.580 (1.933–178.630) | NA | NA |
TAF1 | 1.7 | 0.011 | 18.580 (1.933–178.630) | 0.012 | 14.493 (1.507–139.347) |
EPHB1 | 3.4 | 0.019 | 13.794 (1.542–123.422) | NA | NA |
PIK3C3 | 1.7 | 0.019 | 13.794 (1.542–123.422) | NA | NA |
ZNF703 | 1.7 | 0.019 | 13.794 (1.542–123.422) | NA | NA |
PALB2 | 3.4 | 0.028 | 5.421 (1.195–24.597) | 0.056 | 8.100 (0.946–69.384) |
GATA3 | 5.2 | 0.024 | 6.140 (1.263–29.846) | 0.178 | 4.394 (0.510–37.818) |
FGFR1 | 5.2 | 0.029 | 10.924 (1.276–93.521) | 0.021 | 14.493 (1.507–139.347) |
MAX | 1.7 | 0.029 | 10.924 (1.276–93.521) | 0.021 | 14.493 (1.507–139.347) |
SDHC | 12.1 | 0.074 | 3.917 (0.877–17.507) | 0.003 | 11.892 (2.272–62.246) |
MTOR | 5.2 | 0.052 | 4.442 (0.989–19.956) | 0.024 | 6.301 (1.278–31.072) |
RAF1 | 5.2 | 0.042 | 8.986 (1.082–74.659) | 0.034 | 10.686 (1.194–95.634) |
RECQL4 | 1.7 | 0.042 | 8.986 (1.082–74.659) | 0.034 | 10.686 (1.194–95.634) |
SDHAF2 | 1.7 | 0.042 | 8.986 (1.082–74.659) | 0.034 | 10.686 (1.194–95.634) |