|
Genetic pathway
|
Total patients (n = 58)
|
BCG subgroup (n = 46)
|
|---|
|
P-value
|
Hazard ratio (95% CI)
|
P-value
|
Hazard ratio (95% CI)
|
|---|
|
Qualitative
|
|
Epigenetic-related genes
|
0.020
|
0.278 (0.095–0.814)
|
0.023
|
0.198 (0.049–0.797)
|
|
TP53/cell cycle pathway
|
0.668
|
0.805 (0.299–2.170)
|
0.725
|
0.790 (0.212–2.942)
|
|
RTK-PI3K pathway
|
0.830
|
0.849 (0.192–3.765)
|
0.351
|
0.473 (0.098–2.280)
|
|
SWI/SNF pathway
|
0.182
|
0.424 (0.120–1.497)
|
0.397
|
0.507 (0.105–2.439)
|
|
DNA damage pathway
|
0.554
|
0.710 (0.229–2.204)
|
0.965
|
0.969 (0.242–3.878)
|
|
Alternative splicing pathway
|
0.059
|
0.240 (0.054–1.056)
|
0.289
|
0.427 (0.089–2.056)
|
|
DDR genes
|
0.298
|
2.931 (0.387–22.211)
|
0.632
|
1.662 (0.208–13.306)
|
|
Quantitative
|
|
Epigenetic-related genes
|
0.960
|
0.993 (0.756–1.303)
|
0.877
|
1.030 (0.710–1.494)
|
|
TP53/cell cycle pathway
|
0.942
|
1.016 (0.665–1.553)
|
0.958
|
0.985 (0.566–1.716)
|
|
RTK-PI3K pathway
|
0.096
|
0.686 (0.440–1.069)
|
0.308
|
0.756 (0.441–1.295)
|
|
SWI/SNF pathway
|
0.170
|
0.567 (0.252–1.275)
|
0.379
|
0.671 (0.276–1.632)
|
|
DNA damage pathway
|
0.319
|
0.700 (0.348–1.411)
|
0.582
|
0.810 (0.382–1.716)
|
|
Alternative splicing pathway
|
0.101
|
0.400 (0.134–1.195)
|
0.410
|
0.629 (0.208–1.897)
|
|
DDR genes
|
0.603
|
0.951 (0.788–1.148)
|
0.808
|
0.974 (0.789–1.203)
|
- DDR: DNA damage response and repair; BCG: Bacillus Calmette–Guérin; CI: confidence interval; RTK: receptor tyrosine kinases; PI3K: phosphatidylinositol 3-kinase; SWI/SNF: Switch/sucrose nonfermentable; n: number
