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Fig. 3 | Cancer Cell International

Fig. 3

From: Construction of a novel gene-based model for prognosis prediction of clear cell renal cell carcinoma

Fig. 3

Identification of 5 significantly prognostic genes and their expression data in ccRCC. a Venn diagram of 40 OCGs. 9 upregulated genes with HR > 1. 31 downregulated genes with HR < 1. b LASSO coefficients profiles of 19651 protein-coding genes. c LASSO regression with tenfold cross-validation obtained 14 prognostic genes using minimum lambda value. d Multivariate Cox regression analysis of 5 prognostic genes from BSR. e Expression pattern of the five genes between tumor and normal kidney tissue. f IHC of the five genes in tumor and normal kidney tissue. ccRCC clear cell renal cell carcinoma, OCG overlapping candidate genes, HR hazard ratio, LASSO least absolute shrinkage and selection operator, BSR best subset regression, IHC immunohistochemistry. *p < 0.05, **p < 0.01, ***p < 0.001

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