Fig. 7
From: Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p
Hsa_circ_0011385 knockdown inhibited thyroid cancer growth in vivo. a Xenograft model was established by hypodermic injection of BCPAP cells transfected with hsa_circ_0011385 into BALB/c nude mice. Tumors after 8 weeks post-injection are shown. b, c The tumor volume and weight were evaluated (*P < 0.05, **P < 0.01 vs. NC group). d HE staining was used to assess the pathological conditions of the tumor, and Ki67 expression was detected by IHC assay. Magnification, ×100. Scale bars, 50 µm. e Expression of hsa_circ_0011385 was measured by qRT-PCR assay (**P < 0.01 vs. NC group). f Bax, caspase-3, TIMP, MMP2 and MMP9 expression levels were evaluated by Western blot assay