Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Peng, Qiliang; Cheng, Ming; Li, Ting; Chen, Xiangying; Shen, Yi; Zhu, Yaqun; Xu, Bo

doi:10.1186/s12935-020-1142-1

Cancer Cell International

Table 1 Main characteristics of the studies selected for the meta-analysis

From: Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

First author	Year	Country	Ethnicity	M/F	N	Age	TNM stage	miRNA	Sample souce	Methods	Endpoints	Median follow-up time	Hazard ratio
Xi	2006	Germany	Europeans	10/14	24	62	I–IV	miR-200c	Tissue	RT–PCR	OS	40	0.68 (0.51–0.92)
Toiyama	2014	Japan	Asians	105/77	182	67	I–IV	miR-200c	Blood	RT–PCR	OS	50	0.37 (0.18–0.78)
Toiyama	2014	Japan	Asians	89/67	156	68	I–IV	miR-200c	Tissue	RT–PCR	OS	50	1.79 (0.91–3.57)
Pichler	2014	USA	Americans	71/40	111	60	II–IV	miR-200a	Tissue	RT–PCR	OS	38	2.04 (1.28–3.25)
Diaz	2014	Spain	Europeans	69/58	127	67	I–III	miR-200a	Tissue	RT-PCR	OS	113	1.20 (1.03–1.40)
Diaz	2014	Spain	Europeans	69/58	127	67	I–III	miR-200c	Tissue	RT-PCR	OS	113	1.12 (1.01–1.25)
Maierthaler	2016	Germany	Europeans	162/146	308	70	I–III	miR-200a	Blood	RT-PCR	OS	72	0.95 (0.71–1.26)
Maierthaler	2016	Germany	Europeans	162/146	308	70	I–III	miR-200b	Blood	RT-PCR	OS	72	1.29 (0.96–1.75)
Maierthaler	2016	Germany	Europeans	162/146	308	70	I–III	miR-200c	Blood	RT-PCR	OS	72	1.19 (0.93–1.52)
Maierthaler	2016	Germany	Europeans	130/89	219	68	IV	miR-200a	Blood	RT-PCR	OS	72	0.81 (0.67–0.99)
Maierthaler	2016	Germany	Europeans	130/89	219	68	IV	miR-200b	Blood	RT-PCR	OS	72	0.83 (0.67–1.03)
Maierthaler	2016	Germany	Europeans	130/89	219	68	IV	miR-200c	Blood	RT-PCR	OS	72	0.87 (0.73–1.03)
Sun	2016	USA	Americans	22/25	47	54	I–IV	miR-200b	Blood	RT-PCR	OS	28	0.38 (0.19–0.77)
Slattery	2016	USA	Americans	401/344	745	64	I–IV	miR-200a	Tissue	RT-PCR	OS	50	1.12 (0.95–1.33)
Slattery	2016	USA	Americans	401/344	745	64	I–IV	miR-200a	Tissue	RT-PCR	OS	50	1.01 (0.93–1.10)
Slattery	2016	USA	Americans	401/344	745	64	I–IV	miR-200b	Tissue	RT-PCR	OS	50	1.11 (0.95–1.30)
Slattery	2016	USA	Americans	401/344	745	64	I–IV	miR-200b	Tissue	RT-PCR	OS	50	1.01 (0.90–1.14)
Slattery	2016	USA	Americans	401/344	745	64	I–IV	miR-200c	Tissue	RT-PCR	OS	50	1.08 (0.90–1.28)
Slattery	2016	USA	Americans	213/183	396	64	I–IV	miR-200a	Tissue	RT-PCR	OS	50	1.18 (0.97–1.41)
Slattery	2016	USA	Americans	213/183	396	64	I–IV	miR-200a	Tissue	RT-PCR	OS	50	1.10 (1.01–1.20)
Slattery	2016	USA	Americans	213/183	396	64	I–IV	miR-200b	Tissue	RT-PCR	OS	50	1.41 (1.05–1.89)
Slattery	2016	USA	Americans	213/183	396	64	I–IV	miR-200b	Tissue	RT-PCR	OS	50	1.09 (0.92–1.28)
Slattery	2016	USA	Americans	213/183	396	64	I–IV	miR-200c	Tissue	RT-PCR	OS	50	1.28 (0.96–1.72)
Roh	2018	South Korea	Asians	67/42	109	68	I–IV	miR-200c	Tissue	RT-PCR	OS	35	0.45 (0.16–1.27)
Shelton	2018	USA	Americans	NA	106	NA	I–IV	miR-200a	Tissue	RT-PCR	OS	120	2.27 (1.27–4.35)
Shelton	2018	USA	Americans	NA	108	NA	I–IV	miR-200b	Tissue	RT-PCR	OS	120	2.17 (1.35–3.57)
Santasusagna	2018	Spain	Europeans	31/19	50	72	I–III	miR-200c	Blood	RT-PCR	OS	45	0.81 (0.67–0.99)
Carter	2019	USA	Americans	112/87	199	66	I–IV	miR-200a	Tissue	RT-PCR	OS	96	2.01(1.09–3.72)
Carter	2019	USA	Americans	112/87	199	66	I–IV	miR-200b	Tissue	RT-PCR	OS	96	1.80 (0.98–3.31)
Carter	2019	USA	Americans	112/87	199	66	I–IV	miR-200c	Tissue	RT-PCR	OS	96	1.97(1.08–3.62)

F female, M male, N number, OS overall survival

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