Fig. 6

YAP1 expression was repressed by the FER1L4/miR-92a-3p/FBXW7 axis in prostate cancer cells. a, b Western blotting showed that overexpression of FER1L4 decreased YAP1 protein expression in PC-3 (a) and DU145 cells (b). c, d RT-qPCR showed that overexpression of FER1L4 did not altered YAP1 mRNA expression in PC-3 (c) and DU145 cells (d). e, f MG132 treatment reversed downregulation of YAP1 upon FER1L4 overexpression in PC-3 (e) and DU145 cells (f). g, h The target gene of YAP1 signaling (CTGF, CYR61) was downregulated in PC-3 (g) and DU145 (h) cells transfected with FER1L4. **p < 0.01; ***p < 0.001