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Table 4 Diagnostic efficacy of FPR and GPR used alone or in combination in differentiating patients with AFP-NHCC from other patients

From: Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma

 

Cutoff

Sensitivity (%)

Specificity (%)

PLR

NLR

PPV (%)

NPV (%)

AUC (95% CI)

p

FPRa

11.57

86.67

88.44

7.50

0.15

87.2

88.0

0.935 (0.905–0.957)

< 0.001

GPRa

0.21

67.78

94.47

12.26

0.34

91.7

76.4

0.884 (0.848–0.915)

< 0.001

FPRa + GPRa

0.44

91.11

96.48

25.90

0.09

95.9

92.3

0.977 (0.957–0.990)

< 0.001

FPRb

16.70

46.11

94.02

7.71

0.57

88.3

64.1

0.696 (0.646–0.743)

< 0.001

GPRb

0.23

64.44

61.96

1.69

0.57

62.4

64.0

0.677 (0.626–0.725)

< 0.001

FPRb + GPRb

0.55

67.22

74.46

2.63

0.44

72.0

69.9

0.745 (0.697–0.789)

< 0.001

FPRc

20.72

26.11

93.38

3.94

0.79

82.5

51.5

0.623 (0.568–0.675)

< 0.001

GPRc

0.20

68.89

43.71

1.22

0.71

59.3

54.1

0.617 (0.563–0.670)

< 0.001

FPRc + GPRc

0.42

46.11

81.46

2.49

0.66

74.8

55.9

0.666 (0.612–0.716)

< 0.001

FPRd

11.30

80.00

86.43

5.90

0.23

54.2

95.6

0.914 (0.871–0.946)

< 0.001

GPRd

0.19

60.00

89.95

5.97

0.44

54.5

91.8

0.801 (0.745–0.850)

< 0.001

FPRd + GPRd

0.15

87.50

86.93

6.70

0.14

57.4

97.2

0.943 (0.906–0.969)

< 0.001

FPRe

11.26

86.11

85.93

6.12

0.16

76.9

91.9

0.916 (0.879–0.944)

< 0.001

GPRe

0.21

66.67

94.47

12.06

0.35

86.7

83.9

0.859 (0.814–0.896)

< 0.001

FPRe + GPRe

0.16

89.81

96.48

25.53

0.11

93.3

94.6

0.971 (0.945–0.987)

< 0.001

  1. FPR fibrinogen to prealbumin ratio, GPR gamma-glutamyl transpeptidase to platelet ratio, PLR positive likelihood ratio, NLR negative likelihood ratio, PPV positive predictive value, NPV negative predictive value, CI confidence interval, AUC area under curve, AFP-NHCC alpha-fetoprotein-negative hepatocellular carcinoma, AFP alpha-fetoprotein, CH chronic hepatitis, LC liver cirrhosis, BCLC Barcelona Clinic Liver Cancer
  2. aAFP-NHCC patients vs healthy controls
  3. bAFP-NHCC patients vs AFP-negative CH patients
  4. cAFP-NHCC patients vs AFP-negative LC patients
  5. dAFP-NHCC patients with tumor size < 3 cm vs healthy controls
  6. eAFP-NHCC patients with BCLC-A stage vs healthy controls