Fig. 1

PEG3 expression is decreased and miR-21 expression is elevated in glioma cells and tissues. a Comparison of miR-21 and PEG3 mRNA expression between glioma tissue (n = 71) and normal brain tissue (n = 30). b Comparison of protein expression of PEG3 in glioma tissues (n = 71) and normal brain tissues (n = 30). c Comparison of miR-21 and PEG3 mRNA expression in HA1800, U87, U251, SHG44, A172 and LN299 cells (N = 3). d Comparison of PEG3 protein expression in HA1800, U87, U251, SHG44, A172 and LN299 cells (N = 3). E, Comparison of TGF-β1 and IFN-γ levels in peripheral blood of patients with glioma (n = 71) and healthy subjects (n = 30). F, Survival analysis curve of the effect of miR-21 on prognosis of glioma patients. G, Survival analysis curve of the effect of PEG3 mRNA on prognosis of patients with glioma. *p < 0.05 vs. the HA1800 cells. The measurement data were represented by mean ± standard deviation. The independent t-test was performed for comparisons between two groups, one-way ANOVA was used for comparisons among multiple groups and Tukey’s multiple comparisons test was used for pairwise comparisons after one-way ANOVA. Kaplan–Meier and log-rank test was used for survival analysis