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Fig. 6 | Cancer Cell International

Fig. 6

From: M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3

Fig. 6

BMDM-Exos shuttle miR-21 promotes proliferation, migration and invasion as well as inhibits apoptosis of glioma cells by reducing PEG3. a miR-21 and PEG3 mRNA expression in cells detected by RT-qPCR. b PEG3 protein expression in cells detected by western blot assay. c Cell proliferation tested by EdU assay. d Detection of apoptosis by flow cytometry. e Cell invasion tested by Transwell assay. f Cell migration detected by scratch test. g The protein expression of Bcl-2, Bax, MMP-2 and MMP-9 measured by western blot assay. n = 3. *p < 0.05 vs. the blank group. #p < 0.05 vs. the Exo-inhibitors NC group. The measurement data were represented by mean ± standard deviation. Comparison among multiple groups were conducted by one-way ANOVA followed by Tukey’s multiple comparisons test

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Cancer Cell International

ISSN: 1475-2867

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