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Table 4 Stratification by age and gender for the effect of genetic variants in IL-1B/IL-1RN on the susceptibility of head and neck cancer

From: Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Gene SNP ID Model Genotype Case Control OR (95% CI) p Case Control OR (95% CI) p
Age stratification > 46 years ≤ 46 years
IL-1RN rs17042888 Allele G 449 439 1   362 345 1  
  A 143 163 0.86 (0.66–1.11) 0.248 116 129 0.86 (0.64–1.15) 0.298
Genotype GG 176 157 1   134 124 1  
  GA 97 125 0.70 (0.50–0.98) 0.040* 94 97 0.91 (0.63–1.33) 0.627
  AA 23 19 1.07 (0.56–2.05) 0.831 11 16 0.64 (0.29–1.44) 0.285
Dominant GG 176 157 1   134 124 1  
  GA-AA 120 144 0.75 (0.54–1.04) 0.080 105 113 0.87 (0.61–1.25) 0.463
Recessive GG-GA 273 282 1   228 221 1  
  AA 23 19 1.24 (0.66–2.32) 0.510 11 16 0.67 (0.30–1.48) 0.321
Log-additive     0.86 (0.67–1.12) 0.262    0.86 (0.64–1.16) 0.322
Gender stratification Males Females
IL-1B rs1143643 Allele C 203 219 1   302 346 1  
  T 207 198 1.12 (0.85–1.48) 0.406 358 314 1.31 (1.05–1.62) 0.015*
Genotype CC 50 57 1   64 89 1  
  CT 103 107 1.13 (0.71–1.81) 0.600 174 168 1.44 (0.98–2.12) 0.063
  TT 52 47 1.26 (0.73–2.19) 0.401 92 73 1.76 (1.13–2.74) 0.013*
Dominant CC 50 57 1   64 89 1  
  CT-TT 155 151 1.17 (0.76–1.83) 0.476 266 241 1.54 (1.07–2.21) 0.021*
Recessive CC-CT 153 161 1   238 257 1  
  TT 52 47 1.16 (0.74–1.83) 0.510 92 73 1.36 (0.96–1.94) 0.086
Log-additive     1.13 (0.86–1.48) 0.401    1.32 (1.06–1.65) 0.014*
IL-1RN rs17042888 Allele G 306 306 1   505 478 1  
  A 104 110 0.95 (0.69–1.29) 0.724 155 182 0.81 (0.63–1.03) 0.088
Genotype GG 115 112 1   195 169 1  
  GA 76 82 0.90 (0.60–1.36) 0.624 115 140 0.71 (0.52–0.98) 0.038*
  AA 14 14 0.97 (0.44–2.13) 0.939 20 21 0.83 (0.43–1.58) 0.571
Dominant GG 115 112 1   195 169 1  
  GA-AA 90 96 0.91 (0.62–1.35) 0.646 135 161 0.73 (0.53–0.99) 0.042*
Recessive GG-GA 191 194 1   310 309 1  
  AA 14 14 1.01 (0.47–2.18) 0.977 20 21 0.95 (0.51–1.80) 0.884
Log-additive     0.95 (0.69–1.29) 0.721    0.80 (0.63–1.03) 0.087
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. *p < 0.05 respects the data is statistically significant