Table 4 Stratification by age and gender for the effect of genetic variants in IL-1B/IL-1RN on the susceptibility of head and neck cancer

Age stratification

> 46 years

≤ 46 years

IL-1RN

rs17042888

Allele

G

449

439

1

362

345

1

A

143

163

0.86 (0.66–1.11)

0.248

116

129

0.86 (0.64–1.15)

0.298

Genotype

GG

176

157

1

134

124

1

GA

97

125

0.70 (0.50–0.98)

0.040*

94

97

0.91 (0.63–1.33)

0.627

AA

23

19

1.07 (0.56–2.05)

0.831

11

16

0.64 (0.29–1.44)

0.285

Dominant

GG

176

157

1

134

124

1

GA-AA

120

144

0.75 (0.54–1.04)

0.080

105

113

0.87 (0.61–1.25)

0.463

Recessive

GG-GA

273

282

1

228

221

1

AA

23

19

1.24 (0.66–2.32)

0.510

11

16

0.67 (0.30–1.48)

0.321

Log-additive

0.86 (0.67–1.12)

0.262

0.86 (0.64–1.16)

0.322

Gender stratification

Males

Females

IL-1B

rs1143643

Allele

C

203

219

1

302

346

1

T

207

198

1.12 (0.85–1.48)

0.406

358

314

1.31 (1.05–1.62)

0.015*

Genotype

CC

50

57

1

64

89

1

CT

103

107

1.13 (0.71–1.81)

0.600

174

168

1.44 (0.98–2.12)

0.063

TT

52

47

1.26 (0.73–2.19)

0.401

92

73

1.76 (1.13–2.74)

0.013*

Dominant

CC

50

57

1

64

89

1

CT-TT

155

151

1.17 (0.76–1.83)

0.476

266

241

1.54 (1.07–2.21)

0.021*

Recessive

CC-CT

153

161

1

238

257

1

TT

52

47

1.16 (0.74–1.83)

0.510

92

73

1.36 (0.96–1.94)

0.086

Log-additive

1.13 (0.86–1.48)

0.401

1.32 (1.06–1.65)

0.014*

IL-1RN

rs17042888

Allele

G

306

306

1

505

478

1

A

104

110

0.95 (0.69–1.29)

0.724

155

182

0.81 (0.63–1.03)

0.088

Genotype

GG

115

112

1

195

169

1

GA

76

82

0.90 (0.60–1.36)

0.624

115

140

0.71 (0.52–0.98)

0.038*

AA

14

14

0.97 (0.44–2.13)

0.939

20

21

0.83 (0.43–1.58)

0.571

Dominant

GG

115

112

1

195

169

1

GA-AA

90

96

0.91 (0.62–1.35)

0.646

135

161

0.73 (0.53–0.99)

0.042*

Recessive

GG-GA

191

194

1

310

309

1

AA

14

14

1.01 (0.47–2.18)

0.977

20

21

0.95 (0.51–1.80)

0.884

Log-additive

0.95 (0.69–1.29)

0.721

0.80 (0.63–1.03)

0.087