Fig. 1
From: Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity
Mammary tumor initiation is delayed by a B6 genetic background, resulting in prolonged overall survival. a Whole mounts of #4 mammary glands from Fvb.B6 (n = 6) and Fvb (n = 6) mice at 4 and 7 weeks old. LN = lymph node. b The total area of hyperplastic foci in whole mount mammary glands was measured using Image J. The data represents the mean area of hyperplasia ± SEM from Fvb.B6 (n = 6) and Fvb (n = 6) mice at 4 and 7 weeks old. c The data represents the mean percentage of Ki67 positive cells ± SEM in the hyperplastic lesions of Fvb.B6 (9 weeks) and Fvb (5 weeks) mice (n = 5). d Ki67 immunostaining of mammary gland sections from Fvb.B6 (9 weeks) and Fvb (5 weeks) mice. e Kaplan–Meier curves showing the overall survival of Fvb.B6 (n = 31) and Fvb (n = 33) mice. Data represents the mean ± SEM, *P < 0.05, **P < 0.01, and ***P < 0.001