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Fig. 4 | Cancer Cell International

Fig. 4

From: Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity

Fig. 4

Gene enrichment analyses reveal the heavy involvement of immune function related genes. ac Using the genomic expression data from the mouse model tumors, GO enrichment analyses of the up-regulated DEGs at three stages of breast cancer development were performed. The top 15 terms with the most significant p-value at adenoma (a), late carcinoma of the mammary gland (b), and lung metastasis (c) are plotted. df KEGG enrichment of the up-regulated DEGs at three stages. The top 15 terms with the most significant p-value at adenoma (d), late carcinoma (e), and lung metastasis (f) are plotted. Color gradient ranging from red to blue corresponds to the order of increasing p-values. All DEGs in each tumor stage were used for gene enrichment analyses, GO annotations of biological processes and the KEGG pathway were analyzed using the R package clusterProfiler v3.4.4

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