Fig. 4
From: Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity
Gene enrichment analyses reveal the heavy involvement of immune function related genes. a–c Using the genomic expression data from the mouse model tumors, GO enrichment analyses of the up-regulated DEGs at three stages of breast cancer development were performed. The top 15 terms with the most significant p-value at adenoma (a), late carcinoma of the mammary gland (b), and lung metastasis (c) are plotted. d–f KEGG enrichment of the up-regulated DEGs at three stages. The top 15 terms with the most significant p-value at adenoma (d), late carcinoma (e), and lung metastasis (f) are plotted. Color gradient ranging from red to blue corresponds to the order of increasing p-values. All DEGs in each tumor stage were used for gene enrichment analyses, GO annotations of biological processes and the KEGG pathway were analyzed using the R package clusterProfiler v3.4.4