Fig. 3

Association between CFL-1 protein levels and local dissemination in CRC patients. a Representative IHC images for CFL-1 staining in adjacent normal tissues, in tumor stages (I–IV), and in hepatic metastatic lesions. Scale bar = 100 µm. b Quantification of the IHC score data; this value was calculated using the intensity × area of staining. The P value was derived from the paired Student’s t-test (*P < 0.05). IHC and immunohistochemistry of 49 primary tumors (stages I, n = 13; II, n = 12; III, n = 11; and IV, n = 13), and 10 hepatic metastases