Skip to main content

Table 2 Association between CFL-1 IHC score and clinicopathological features of CRC patients

From: Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Features n CFL-1 IHC score, n (%) χ2 value P-valuea
Low High
Gender
 Male 23 10(43.4) 13(56.6) 0.208 0.648
 Female 26 13(50) 13(50)   
Age at surgery (years)
 ≥ 65 27 11(40.7) 16(59.3) 0.927 0.335
 < 65 22 12(54.5) 10(45.5)   
Localization
 Colon ascendens 14 3(21.4) 11(78.6) 6.381 0.09
 Colon descendens 10 5(50) 5(50)   
 Colon transversum 3 1(33.3) 2(66.7)   
  Colon sigmoideum/rectum 22 14(63.6) 8(36.4)   
Tumor type
 Adenocarcinoma 40 20(50) 20(50) 0.819 0.364
 Adenocarcinoma/mucinous 9 3(33.3) 6(66.7)   
Tumor grade
 Well differentiated 1 1 (100) 0 1.355 0.508
 Moderately differentiated 45 21(46.6) 24(53.4)   
 Poorly differentiated 3 1(33.3) 2(66.7)   
T stage (AJCC)
 T1/2 15 10(66.7) 5(33.3) 7.985 0.001**
 T3 16 3(18.7) 13(81.3)   
 T4 18 10(55.5) 8(44.5)   
Lymph node metastasis
 Present 19 5(26.3) 14(73.7) 5.299 0.02*
 Absent 30 18(60) 12(40)   
Liver metastasis
 Present 13 7(53.8) 6(46.2) 0.339 0.560
 Absent 36 16(44.4) 20(55.6)   
Lymphovascular invasion
 Present 13 7(53.8) 6(46.2) 0.339 0.560
 Absent 36 16(44.4) 20(55.6)   
Perineural invasion
 Present 11 6(54.5) 5(45.6) 0.329 0.565
 Absent 38 17(44.7) 21(55.3)   
Tumor size (cm3 )
 ≥ 33 24 10(41.7) 14(58.3) 0.525 0.468
 < 33 25 13(52) 12(48)   
  1. aP value obtained from χ2 test
  2. CRC colorectal cancer, AJCC American Joint Committee on Cancer