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Table 3 Association between SSH1 IHC score and clinicopathological features of CRC patients

From: Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Features n SSH1 IHC Score, n (%) χ2 value P-valuea
Low High
Gender
 Male 23 9(39.1) 14(60.9) 1.061 0.303
 Female 26 14(53.8) 12(46.2)   
Age at surgery (years)
 ≥ 65 27 14(51.8) 13(48.2) 0.582 0.442
 < 65 22 9(40.9) 13(59.1)   
Localization
 Colon ascendens 14 6(42.8) 8(57.2) 2.773 0.428
 Colon descendens 10 7(70) 3(30)   
 Colon transversum 3 1(33.3) 2(66.7)   
 Colon sigmoideum/rectum 22 9(40.9) 13(59.1)   
Tumor type
 Adenocarcinoma 40 20(50) 20(50) 0.819 0.364
 Adenocarcinoma/mucinous 9 3(33.3) 6(66.7)   
Tumor grade
 Well differentiated 1 1(100) 0 1.355 0.508
 Moderately differentiated 45 21(46.6) 24(53.4)   
 Poorly differentiated 3 1(33.3) 2(66.7)   
T stage (AJCC)
 T1/2 15 8(53.3) 7(46.7) 2.364 0.306
 T3 16 5(31.3) 11(68.7)   
 T4 18 10(55.5) 8(44.5)   
Lymph node metastasis
 Present 19 5(26.3) 14(73.7) 5.299 0.02*
 Absent 30 18(60) 12(40)   
Liver metastasis
 Present 13 7(53.8) 6(46.2) 0.339 0.560
  Absent 36 16(44.4) 20(55.6)   
Lymphovascular invasion
 Present 13 6(46.1) 7(53.9) 0.004 0.947
 Absent 36 17(47.3) 19(52.7)   
Perineural invasion
 Present 11 5(45.5) 6(54.5) 0.125 0.910
 Absent 38 18(47.4) 20(52.6)   
Tumor size (cm3)
 ≥ 33 24 12(50) 12(50) 0.177 0.674
 < 33 25 11(44) 14(56)   
  1. aP value obtained from χ2 test
  2. CRC colorectal cancer, AJCC American Joint Committee on Cancer