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Table 4 Association between LIMK1 IHC score and clinicopathological features of CRC patients

From: Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Features n LIMK1 IHC score, n (%) χ2 value P-valuea
Low High
Gender
 Male 23 11(47.8) 12(52.2) 0.023 0.879
 Female 26 13(50) 13(50)   
Age at surgery (years)
 ≥ 65 27 13(48.1) 14(51.9) 0.016 0.897
 < 65 22 11(50) 11(50)   
Localization
 Colon ascendens 14 5(35.7) 9(64.3) 5.761 0.123
 Colon descendens 10 5(50) 5(50)   
 Colon transversum 3 0 3(100)   
 Colon sigmoideum/rectum 22 14(63.6) 8(36.4)   
Tumor type
 Adenocarcinoma 40 21(52.5) 19(47.5) 1.080 0.298
 Adenocarcinoma/mucinous 9 3(33.3) 6(66.7)   
Tumor grade
 Well differentiated 1 1(100) 0 4.003 0.135
 Moderately differentiated 45 23(51.1) 22(48.9)   
 Poorly differentiated 3 0 3(100)   
T stage (AJCC)
 T1/2 15 7(46.7) 8(53.3) 0.046 0.977
 T3 16 8(50) 8(50)   
 T4 18 9(50) 9(50)   
Lymph node metastasis 0.032 0.857
 Present 19 9(47.4) 10(52.6)   
 Absent 30 15(50) 15(50)   
Liver metastasis
 Present 13 7(53.9) 6(46.1) 0.167 0.682
 Absent 36 17(47.2) 19(52.8)   
Lymphovascular invasion
 Present 13 6(46.1) 7(53.9) 0.056 0.812
 Absent 36 18(50) 18(50)   
Perineural invasion
 Present 11 6(54.5) 5(45.5) 0.012 0.910
 Absent 38 20(52.6) 18(47.4)   
Tumor size (cm3)
 ≥ 33 24 13(54.1) 11(45.9) 0.506 0.476
 < 33 25 11(44) 14(56)   
  1. aP value obtained from χ2 test
  2. CRC colorectal cancer, AJCC American Joint Committee on Cancer