Table 1 The potential therapeutic effects of Res in GC therapy
Cell line/Animal mod-el | Dose | Duration | Outcomes | Refs. |
|---|---|---|---|---|
Human gastric cancer cell lines SGC7901 and BGC823 | 0, 5, 10, 25, 50, 100, 200 and 400 µM | 24, 48 and 72 h | Inhibition of MALAT1-induced EMT | [63] |
Human gastric cancer SGC-7901 cell line | 0, 100, 200, 300 and 400 µmol/L | 48 h | Suppressing Hh signaling pathway is associated with EMT inhibition | [93] |
SGC7901 cells | 35.69 µM | 72 h | Administration of Res stimulates apoptotic cell death and cell cycle arrest in GC cells | [99] |
Human gastric cancer SNU-1 cells | 0, 10, 50 and 100 µM | 24 h | Induction of apoptosis and reduced viability of cancer cells | [100] |
Human gastric adenocarcinoma SGC7901 cells | 0, 25, 50, 100 and 200 µmol/L | 48 h | Stimulation of apoptotic cell death and DNA damage through enhancing the ROS production | [101] |
Human GC cell lines AGS Nude mice xenograft model | 0, 5, 10, 25, 50, 100 and 200 µM 40 mg/kg | 24 h 4 weeks | Induction of cell cycle arrest and senescence | [110] |
Balb/c-nu/nu mice BGC823 cells | 0.1, 1, 5, 10, 20, 50 and 100 µg/ml 10 mg/kg | 24 h 3 days | A significant reduction in tumor burden and an increase in apoptosis | [111] |
Human gastric cancer SGC-7901 cell line | 0, 100, 200, 300 and 400 µmol/L | 48 h | Suppressing Hh signaling pathway is associated with EMT inhibition | [93] |
SGC7901 cells | 35.69 µM | 72 h | Administration of Res stimulates apoptotic cell death and cell cycle arrest in GC cells | [99] |
SGC-7901 cells | 50, 200 and 400 µM | 24 h | Induction of apoptosis by down-regulation of NF-κB | [112] |
Human gastric cancer cell lines | 0, 10, 20, 30, 40, 50 and 100 µM | 48 h | Inhibition of IL-6-induced Raf-MAPK | [113] |
Human gastric cancer cell lines that were either sensitive or resistant to cytostatic drugs | 30 and 50 µM | 72 h | Inhibition of MDR by down-regulation of ABCB1, P-gp, ANXA1 and TXN | [114] |
Human gastric carcinoma SGC-7901 cells Nude mice | 25 and 50 µM 50 mg/kg | 24 h 21 days | Stimulation of apoptotic cell death in GC cells through mitochondrial pathway | [115] |
Human gastric cancer cells SGC7901 and MGC803 Nude mice inoculated subcutaneously with SGC7901/DOX cells | 50 mg/L 50 mg/kg | 48 h 4 weeks | Res activates PTEN to down-regulate Akt resulting in EMT-mediated drug resistance | [168] |
Human gastric adenocarcinoma cell line MGC803 | 0, 50, 100 and 200 µM | 24 h | Inhibition of PI3K/Akt signaling pathway through PTEN down-regulation significantly induces cell cycle arrest | [167] |