Fig. 5From: Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to activate the hedgehog pathway in bladder cancerROC1 expression in human bladder cancer tissues. a The expression of ROC1, SUFU, and Gli2 proteins was immunohistochemically analyzed in human bladder cancer tissues. Representative immunohistochemical images of low-grade or high-grade cancer are shown. b Association of ROC1, SUFU, and Gli2 expression with the clinicopathological grade. The expression levels were divided into two categories (low vs. high) according to their immunoreactivity scores and were associated with the cancer pathological grade (low-grade vs. high-grade) by using the χ2 test. Scale bar, 50 µmBack to article page