From: LiCl induces apoptosis via CHOP/NOXA/Mcl-1 axis in human choroidal melanoma cells
Group Date | 1/10 | 1/13 | 1/16 | 1/19 | 1/22 | 1/25 |
---|---|---|---|---|---|---|
a Mice weight(g) | ||||||
Normal saline | ||||||
1 | 14.57 | 15.46 | 16.68 | 17.18 | 16.88 | 18.00 |
2 | 17.75 | 17.10 | 19.80 | 20.00 | 20.01 | 21.00 |
3 | 15.62 | 15.48 | 16.91 | 17.37 | 17.39 | 18.23 |
4 | 14.42 | 14.16 | 16.47 | 16.94 | 16.39 | 18.78 |
5 | 13.68 | 15.40 | 16.03 | 16.53 | 15.53 | 17.63 |
LiCl | ||||||
1 | 16.86 | 17.43 | 19.08 | 18.75 | 17.44 | 19.28 |
2 | 16.90 | 16.23 | 17.85 | 18.33 | 17.90 | 19.47 |
3 | 13.11 | 15.26 | 16.66 | 17.36 | 17.03 | 18.14 |
4 | 16.88 | 17.61 | 19.19 | 19.35 | 17.89 | 18.05 |
5 | 13.53 | 15.30 | 16.90 | 17.11 | 16.32 | 17.24 |
B Tumor volume (mm3) | ||||||
Normal saline | ||||||
1 | ||||||
L | 6.86 | 8.04 | 9.11 | 11.03 | 12.26 | 13.14 |
W | 4.73 | 5.62 | 7.70 | 9.47 | 9.82 | 10.15 |
V | 76.74 | 126.50 | 270.07 | 494.59 | 591.13 | 676.86 |
2 | ||||||
L | 6.49 | 7.86 | 8.70 | 10.02 | 11.97 | 12.19 |
W | 4.62 | 5.67 | 7.61 | 10.84 | 10.43 | 11.54 |
V | 69.26 | 126.35 | 251.92 | 544.17 | 651.08 | 811.68 |
3 | ||||||
L | 6.00 | 8.27 | 9.95 | 11.59 | 13.06 | 13.60 |
W | 5.97 | 6.33 | 8.14 | 8.77 | 9.39 | 9.91 |
V | 106.92 | 165.68 | 329.64 | 445.71 | 575.76 | 667.82 |
4 | ||||||
L | 6.11 | 9.88 | 11.35 | 13.82 | 14.89 | 16.90 |
W | 4.59 | 7.30 | 8.91 | 9.55 | 10.86 | 10.91 |
V | 64.36 | 263.25 | 450.53 | 630.21 | 878.06 | 1005.79 |
5 | ||||||
L | 6.48 | 5.40 | 8.00 | 10.35 | 11.45 | 12.45 |
W | 4.53 | 5.58 | 6.62 | 8.05 | 9.58 | 10.02 |
V | 66.49 | 81.36 | 175.30 | 335.35 | 525.42 | 624.99 |
LiCl | ||||||
1 | ||||||
L | 6.48 | 7.98 | 9.74 | 9.82 | 11.01 | 11.22 |
W | 5.61 | 6.63 | 8.28 | 9.15 | 9.35 | 9.99 |
V | 101.97 | 175.39 | 333.88 | 411.08 | 481.26 | 559.87 |
2 | ||||||
L | 5.45 | 5.60 | 5.93 | 5.58 | 6.52 | 6.62 |
W | 5.45 | 5.40 | 5.36 | 5.57 | 5.13 | 5.09 |
V | 80.94 | 81.65 | 85.18 | 86.56 | 85.79 | 85.76 |
3 | ||||||
L | 6.14 | 7.23 | 8.04 | 10.34 | 11.59 | 12.20 |
W | 5.21 | 5.23 | 7.76 | 8.27 | 8.53 | 8.90 |
V | 83.33 | 98.88 | 242.07 | 353.59 | 421.65 | 483.18 |
4 | ||||||
L | 5.09 | 5.87 | 6.13 | 7.21 | 7.33 | 8.05 |
W | 5.09 | 5.62 | 6.12 | 6.45 | 8.00 | 8.21 |
V | 65.94 | 92.70 | 114.80 | 149.98 | 214.92 | 266.01 |
5 | ||||||
L | 5.82 | 6.58 | 8.72 | 8.94 | 9.18 | 10.14 |
W | 5.82 | 7.07 | 9.35 | 9.58 | 9.83 | 10.44 |
V | 98.57 | 153.05 | 355.48 | 382.83 | 414.19 | 536.71 |