Table 4 Multivariate analysis of clinical features and risk score with Cox proportional hazard model

Age (< 65 vs. ≥ 65)

1.418 (0.766–2.625)

Gender (female vs. male)

0.856 (0.471–1.556)

BMI (< 25 vs. ≥ 25)

1.495 (0.852–2.623)

Histological grade

 G1

1

 G2

1.369 (0.391–4.799)

 G3

1.836 (0.528–6.383)

 G4

3.431 (0.695–16.929)

Clinical stage

 Stage I/II

1

 Stage III/IV

0.995 (0.127–7.817)

T stage

 T1/2

1

 T3/4

2.176 (0.269–17.610)

AFP (< 300 vs. ≥ 300)

0.902 (0.469–1.736)

Vascular invasion

 None

1

 Mico

1.201 (0.616–2.340)

 Macro

3.322 (1.208–9.141)

Risk (high vs. low)

2.002 (1.051–3.812)