Fig. 3

EBV-induced oncogenesis through the JAK/STAT signaling pathway. When JAK is activated, it can phosphorylate STAT, and then dimeric STAT is exposed to the nuclear signal and enters the nucleus to participate in regulating gene expression. LMP1 can activate JAKs and then activate the STAT dimer, which promotes the corresponding transcriptional regulation in the nucleus and can provide feedback and enhance the regulation of its own expression. LMP1 enhances the transcription of AP-1 through JAK/STAT and promotes the expression of PD-L1 to avoid immune surveillance. LMP1 and LMP2A can activate HLX to inhibit apoptosis