Fig. 4

EBV-induced oncogenesis through the MAPK signaling pathway. LMP1 can activate ERK, JNK, and p38 and reduce the expression of DUSP6 and DUSP8 to promote cell proliferation and enhance c-JUN to promote the occurrence of EMT. β1 integrin can promote the expression of LMP1 and activate FAK, which will promote cell proliferation. EBV-miRNA-BART13-3P and EBV-miRNA-BART22 inhibit the upstream and downstream MAPK pathways, promote EMT, and resist apoptosis, respectively