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Fig. 5 | Cancer Cell International

Fig. 5

From: Protein–protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer

Fig. 5

Pathway enrichment analysis between differential expression groups of TMEM17. a Significantly dysregulated pathways were identified by GSEA in the CIT cohort for cancer hallmark pathways. Top ten pathways were selected for presentation by absolute enrichment score (positive score is green and negative score is red). b GSEA plot of the Hallmarks Wnt/ β-catenin signaling in the CIT cohort. c GSEA plot of Willert Wnt signalling in the CIT cohort. d Immunoblotting assay of the expression of TMEM17 and several Wnt signaling markers proteins from CRC cells with scramble or TMEM siRNA. (Left) Immunoblotting assay of the expression of TMEM17 and several Wnt signaling markers proteins from CRC cells with vector or TMEM17. (Right) e GSEA plot of Boquest Stem Cell signalling and Beier Glioma Stem Cell signalling in the CIT cohort

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Cancer Cell International

ISSN: 1475-2867

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