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Table 2 The relationship between miR-1182, miR-let-7a and clinicopathological characteristics of patients with CCA

From: MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1

Influence factors miR-1182 miR-let-7a
High Low p value HIGH LOW p value
Gender
 Male
  34 14 20 0.289 17 17 0.74
 Female
  22 6 16   10 12  
Age
 ≥ 55
  20 7 13 0.934 9 11 0.72
 < 55
  36 13 23   18 18  
Tumor size
 ≥ 2 cm
  16 6 10 0.86 7 9 0.672
 < 2 cm
  40 14 26   20 20  
TNM stage
 I–II
  22 17 5  < 0.001 18 4  < 0.001
 III–IV
  34 3 31   9 25  
Differentiation degree
 High
  17 15 2  < 0.001 15 2  < 0.001
 Moderate
  19 4 15   10 9  
 Low
  20 1 19   2 18  
LNM
 Yes
  27 1 26  < 0.001 3 24  < 0.001
 No
  29 19 10   24 5  
  1. The expression of miR-1182 and miR-let-7a was not significantly different from the age, sex and tumor size of patients, but the expression was significantly correlated with patient TNM staging, degree of differentiation and LNM (p < 0.001)
  2. miR-1182 microRNA1182, miR-let-7a microRNA-let-7a, TNM tumor nodes metastasis, LNM lymph node metastasis