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Table 2 The relationship between miR-1182, miR-let-7a and clinicopathological characteristics of patients with CCA

From: MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1

Influence factors

miR-1182

miR-let-7a

High

Low

p value

HIGH

LOW

p value

Gender

 Male

  34

14

20

0.289

17

17

0.74

 Female

  22

6

16

 

10

12

 

Age

 ≥ 55

  20

7

13

0.934

9

11

0.72

 < 55

  36

13

23

 

18

18

 

Tumor size

 ≥ 2 cm

  16

6

10

0.86

7

9

0.672

 < 2 cm

  40

14

26

 

20

20

 

TNM stage

 I–II

  22

17

5

 < 0.001

18

4

 < 0.001

 III–IV

  34

3

31

 

9

25

 

Differentiation degree

 High

  17

15

2

 < 0.001

15

2

 < 0.001

 Moderate

  19

4

15

 

10

9

 

 Low

  20

1

19

 

2

18

 

LNM

 Yes

  27

1

26

 < 0.001

3

24

 < 0.001

 No

  29

19

10

 

24

5

 
  1. The expression of miR-1182 and miR-let-7a was not significantly different from the age, sex and tumor size of patients, but the expression was significantly correlated with patient TNM staging, degree of differentiation and LNM (p < 0.001)
  2. miR-1182 microRNA1182, miR-let-7a microRNA-let-7a, TNM tumor nodes metastasis, LNM lymph node metastasis