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Fig. 3 | Cancer Cell International

Fig. 3

From: CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma

Fig. 3

Knockout of CALM1 and application of EGFR inhibitor can synergistically inhibit the invasion and migration of ESCC. a, b, variation of invasive and migration ability was assessed by Transwell assay and Wound-healing assays in KYSE150 and Eca109 cell lines. c Colony-formation assay to quantify the combined effect of CALM1 and EGFR on ESCC viability. d Correspondingly, expression variation of biomarkers of ESCC cell lines KYSE150 and Eca109 related to EMT on protein level using immunoblotting. CALM1 calmodulin1, EGFR epidermal growth factor receptor. ESCC esophageal squamous cell carcinoma, EMT epithelial-mesenchymal transition. *P < 0.05, **p < 0.01, ***p < 0.001 (Student's t-test)

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Cancer Cell International

ISSN: 1475-2867

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