Fig. 7

LINC00958/ mir-211-5p/ CENPK axis promotes TSCC proliferation via regulating cell-cycle process and activating the JAK/ STAT3 signaling pathway. a GSEA revealed that cell cycle related biological functions were enriched in response to high CENPK expression. b RT-qPCR of c-myc, cyclin D and cyclin E in CAL-27 cells overexpression or silencing CENPK. c The protein levels of c-myc, cyclin D, cyclin E, Rb and p-Rb in CAL-27 cells overexpression or silencing CENPK. d GSEA revealed that the JAK/STAT3 signaling pathway was enriched in response to high CENPK expression. e IHC of CENPK and p-STAT3 expression in the xenografts. f The protein levels of JAK1, p-JAK1, STAT3, p-STAT3 in CAL-27 cells overexpression or silencing CENPK. g The cell cycle related and JAK/STAT3 signaling related protein levels in CAL-27 cells co-transfected with pcDNA-LINC00958 and miR-211-5p mimics or si-CENPK. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001