Table 1 The expression of the top 20 upregulated and downregulated genes in the cetuximab resistant CACO2
Gene symbol | Normalized Signal Value | Log [fold change] | P value | Adjustive p value | |||||
|---|---|---|---|---|---|---|---|---|---|
Sensitive | Resistant | ||||||||
Sam.1 | Sam.2 | Sam.3 | Sam.1 | Sam.2 | Sam.3 | ||||
Top 20 of up-regulated genes | |||||||||
DRD2 | 1.253 | 1.265 | 1.252 | 7.414 | 7.471 | 7.331 | 6.149 | 2.76E–09 | 5.19E–05 |
SLC2A5 | 8.931 | 9.006 | 9.037 | 13.002 | 12.996 | 12.980 | 4.001 | 2.62E–08 | 9.87E–05 |
CADM1 | 4.659 | 4.421 | 4.556 | 9.133 | 9.344 | 9.152 | 4.664 | 4.91E–08 | 1.11E–04 |
RTP3 | 1.232 | 1.300 | 1.161 | 4.731 | 4.881 | 4.823 | 3.581 | 8.34E–08 | 1.14E–04 |
NPR2 | 6.365 | 6.349 | 6.191 | 10.112 | 10.297 | 10.310 | 3.938 | 9.25E–08 | 1.16E–04 |
SERPINF1 | 10.281 | 10.168 | 10.135 | 13.543 | 13.716 | 13.685 | 3.453 | 1.29E–07 | 1.26E–04 |
BASP1 | 6.890 | 6.446 | 6.407 | 11.922 | 12.156 | 12.069 | 5.468 | 1.33E–07 | 1.26E–04 |
LAMA1 | 6.237 | 6.392 | 6.334 | 9.733 | 9.873 | 9.949 | 3.531 | 1.42E–07 | 1.26E–04 |
THPO | 1.271 | 1.275 | 1.418 | 4.485 | 4.429 | 4.562 | 3.171 | 1.75E–07 | 1.26E–04 |
ACTA1 | 4.330 | 3.837 | 4.273 | 9.829 | 9.596 | 9.503 | 5.496 | 1.80E–07 | 1.26E–04 |
SERPINF2 | 11.096 | 11.257 | 10.992 | 14.287 | 14.346 | 14.294 | 3.194 | 2.59E–07 | 1.35E–04 |
ANXA8 | 9.699 | 9.805 | 9.662 | 12.950 | 13.168 | 12.871 | 3.274 | 3.77E–07 | 1.73E–04 |
DPYSL3 | 7.688 | 7.165 | 7.810 | 12.588 | 12.744 | 12.676 | 5.115 | 4.15E–07 | 1.82E–04 |
PDGFRA | 1.312 | 1.304 | 1.231 | 5.091 | 5.216 | 4.782 | 3.748 | 4.25E–07 | 1.82E–04 |
SDC2 | 4.645 | 4.510 | 4.744 | 7.533 | 7.547 | 7.725 | 2.968 | 5.37E–07 | 2.10E–04 |
ORM1 | 12.007 | 12.089 | 11.909 | 14.634 | 14.613 | 14.758 | 2.667 | 5.43E–07 | 2.10E–04 |
ORM2 | 12.062 | 12.209 | 12.006 | 14.728 | 14.646 | 14.739 | 2.612 | 5.85E–07 | 2.10E–04 |
ADM | 10.696 | 10.620 | 10.518 | 13.201 | 13.321 | 13.175 | 2.621 | 5.92E–07 | 2.10E–04 |
ADAM19 | 9.666 | 9.526 | 9.323 | 12.874 | 12.710 | 12.676 | 3.248 | 6.38E–07 | 2.22E–04 |
CCDC3 | 9.139 | 9.112 | 8.781 | 12.448 | 12.206 | 12.351 | 3.324 | 9.05E–07 | 2.59E–04 |
Top 20 of down-regulated genes | |||||||||
GC | 6.719 | 6.693 | 6.902 | 1.271 | 1.278 | 1.263 | –5.500 | 8.90E–09 | 6.23E–05 |
SCIN | 6.839 | 6.926 | 7.093 | 1.350 | 1.309 | 1.335 | –5.621 | 9.94E–09 | 6.23E–05 |
ST6GALNAC1 | 7.759 | 7.546 | 7.389 | 1.269 | 1.309 | 1.356 | –6.253 | 1.39E–08 | 6.51E–05 |
PADI2 | 8.533 | 8.655 | 8.104 | 1.339 | 1.256 | 1.373 | –7.108 | 3.18E–08 | 9.95E–05 |
MUC13 | 14.179 | 13.905 | 14.478 | 7.486 | 7.521 | 7.534 | –6.674 | 4.05E–08 | 1.09E–04 |
SULF2 | 9.285 | 8.985 | 9.273 | 3.737 | 3.522 | 3.850 | –5.478 | 5.92E–08 | 1.11E–04 |
COL17A1 | 8.492 | 8.749 | 8.525 | 2.545 | 2.030 | 2.235 | –6.319 | 6.07E–08 | 1.11E–04 |
FAM83E | 10.754 | 10.695 | 10.635 | 6.944 | 7.056 | 6.897 | –3.729 | 6.48E–08 | 1.11E–04 |
HLA-DMB | 5.666 | 5.548 | 5.337 | 1.177 | 1.237 | 1.244 | –4.298 | 8.23E–08 | 1.14E–04 |
NPAS2 | 5.506 | 5.310 | 5.640 | 1.250 | 1.186 | 1.173 | –4.282 | 8.47E–08 | 1.14E–04 |
PNLIPRP2 | 9.009 | 8.923 | 8.898 | 4.505 | 4.836 | 4.560 | –4.310 | 1.04E–07 | 1.22E–04 |
LCN2 | 11.287 | 11.659 | 11.027 | 4.564 | 4.442 | 4.834 | –6.711 | 1.24E–07 | 1.26E–04 |
SRPX | 9.803 | 9.612 | 9.507 | 5.937 | 5.942 | 5.842 | –3.734 | 1.53E–07 | 1.26E–04 |
HOXB9 | 10.762 | 10.582 | 10.682 | 7.503 | 7.485 | 7.573 | –3.155 | 1.66E–07 | 1.26E–04 |
BTNL3 | 5.120 | 5.170 | 5.485 | 1.188 | 1.231 | 1.215 | –4.047 | 1.77E–07 | 1.26E–04 |
TMC5 | 7.201 | 6.746 | 7.401 | 1.274 | 1.203 | 1.339 | –5.844 | 1.77E–07 | 1.26E–04 |
APOBEC1 | 6.060 | 5.632 | 6.092 | 1.210 | 1.170 | 1.156 | –4.749 | 1.78E–07 | 1.26E–04 |
S100A9 | 10.469 | 10.404 | 9.896 | 3.540 | 3.948 | 3.972 | –6.436 | 2.00E–07 | 1.31E–04 |
DDIT4L | 6.599 | 6.789 | 7.249 | 1.229 | 1.281 | 1.306 | –5.607 | 2.07E–07 | 1.31E–04 |
PI3 | 13.824 | 13.941 | 13.611 | 9.571 | 9.226 | 9.378 | –4.400 | 2.12E–07 | 1.31E–04 |